# Endpoints

## Registries

The disease endpoints were defined using nationwide registries:

* [Drug purchase and  Drug Reimbursement](https://www.kela.fi/web/en/research-data-requests)
* [Digital and Population Data Services Agency](https://dvv.fi/en/digital-and-population-data-services-agency)
* [Statistics Finland](https://www.stat.fi/til/ksyyt/index_en.html)
* [Register of primary health care visits: AVOHILMO](https://thl.fi/en/web/thlfi-en/statistics/information-on-statistics/register-descriptions/register-of-primary-health-care-visits)
* [Care Register for Health Care: HILMO](https://thl.fi/en/web/thlfi-en/statistics/information-on-statistics/register-descriptions/care-register-for-health-care)
* [Finnish cancer registry](https://syoparekisteri.fi/assets/files/2017/07/variable_list_eng_net.pdf)

We harmonized over the International Classification of Diseases (ICD) revisions 8, 9 and 10, cancer-specific ICD-O-3, (NOMESCO) procedure codes, Finnish-specific Social Insurance Institute (KELA) drug reimbursement codes and ATC-codes.

These registries spanning decades were electronically linked to the cohort baseline data using the unique national personal identification numbers assigned to all Finnish citizens and residents.

A full list of FinnGen endpoints is [available online](https://www.finngen.fi/en/researchers/clinical-endpoints) for release 4.

## Excluded endpoints

The endpoints with fewer than 100 cases, near-duplicate endpoints, and developmental “helper” endpoints were excluded from the final PheWas (column “OMIT”).

Endpoints with N<150 are not released by [THL](https://thl.fi/en/web/thlfi-en) (Finnish Institute for Health and Welfare).

## Risteys

[risteys.finngen.fi](https://risteys.finngen.fi/) (*Risteys = intersection* in Finnish) allows browsing of the FinnGen data at the phenotype level, including endpoint definitions, statistics about number of individuals, gender distribution, and longitudinal relationships.