We used the SAIGE (version software for running the R4 GWAS.

SAIGE is a mixed model logistic regression R/C++ package, able to account for related samples.

We analyzed:

  • ​2,444 endpoints

  • 176,899 samples

  • 16,962,023 variants

We included the following covariates in the model: sex, age, 10 PCs, genotyping batch.

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