> For the complete documentation index, see [llms.txt](https://finngen.gitbook.io/documentation/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://finngen.gitbook.io/documentation/r7/methods/genotype-imputation/sisu-reference-panel.md).

# SISu reference panel

[SISu](http://sisuproject.fi/) v3 consists of 3,775 WGS of Finnish individuals from six research cohorts:

1. METSIM (PIs Markku Laakso and Mike Boehnke) 
2. FINRISK (PI Pekka Jousilahti)
3. Health2000 (PI Seppo Koskinen)
4. Finnish Migraine Family Study (PI Aarno Palotie)
5. Merck/Tienari samples (PI Pentti Tienari)
6. MESTA samples (PI Jaana Suvisaari)

High-coverage (25-30x) WGS data used to develop the SISu v3 reference panel were generated at the Broad Institute of MIT and Harvard and at the McDonnell Genome Institute at Washington University; and jointly processed at the Broad Institute.


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