LD estimation

The BCORarrow-up-right files were created using LDstorearrow-up-right from the Finnish SISu panel v4.2.

The panel has been divided per chromosome. For example, to use the LD information in the first chromosome, FG_LD_chr1.bcor would be the file to use.

Settings used

  • number of samples: 3775

  • window size: 1500 kb

  • accuracy: low

  • number of threads: 96

  • LD threshold to include correlations: 0.05

Example usage

LDstore v1.1arrow-up-right can be downloaded via:

wget http://www.christianbenner.com/ldstore_v1.1_x86_64.tgz

And an example to extract variant range 20 Mb - 50 Mb from chromosome 7 is as follows:

ldstore --bcor FG_LD_chr7.bcor --incl-range 20000000-50000000 --table output_file_name.table

Note

It is not preferred to use these LD estimate files for e.g. fine-mapping, since many of the fine-mapping methods (e.g. SuSiE) require in-sample LD information for good results!

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