GWAS

We used the SAIGE software for running the R2 GWAS.

SAIGE is a mixed model logistic regression R/C++ package, able to account for related samples.

We analyzed:

• ​1,122 endpoints

• 96,499 samples

• 17,054,975 variants

We included the following covariates in the model: sex, age, 10 PCs, genotyping batch.