GWAS

We used the SAIGE (r3 release) software for running the R3 GWAS.

SAIGE is a mixed model logistic regression R/C++ package, able to account for related samples.

We analyzed:

• ​ 1,801 endpoints

• 135,638 samples

• 16,962,023 variants

We included the following covariates in the model: sex, age, 10 PCs, genotyping batch.