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R4
R4
  • Introduction
  • Data download
  • Data description
  • Data releases
  • How to cite
  • Methods
    • Participating biobanks/cohorts
    • Genotypes
      • Genotype data
      • Genotype imputation
      • SISu reference panel
      • Software used
      • LD estimation
    • Endpoints
    • GWAS
      • Sample QC and PCA
      • Association tests
    • Fine-mapping
    • Contact
    • Github
    • FinnGen
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  1. Methods

Fine-mapping

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Last updated 4 years ago

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To identify potential causal variants in GWAS signals, we fine-mapped each genome-wide significant (p < 5e-8) region from the 2,444 GWAS endpoints. Each region was fine-mapped with SuSiE and FINEMAP. We used in-sample LD for fine-mapping.

We used a 3-megabase window (+- 1.5M) around each lead variant, merged overlapping regions into one, and used these regions for fine-mapping.