GWAS

We used the SAIGE (version 0.35.8.8) software for running the R4 GWAS.

SAIGE is a mixed model logistic regression R/C++ package, able to account for related samples.

We analyzed:

• ​2,444 endpoints

• 176,899 samples

• 16,962,023 variants

We included the following covariates in the model: sex, age, 10 PCs, genotyping batch.