Pairwise endpoint genetic correlation format

This pipeline produces a single file, containing all pairwise genetic correlations between multiple phenotypes.

Its name is structured as finngen_R[?]_[EUR/FIN].ldsc.summary.tsv where EUR/FIN changes based on the LD panel used.

(This refers to genetic correlation, in Risteys you can also see the number of shared cases between endpoints.)

Column name

Description

p1

Phenotype 1

p2

Phenotype 2

rg

Genetic correlation

se

Standard error

z

z-score

p

pvalue

h2_obs

heritabilty of p1

h2_obs_se

SE of heritability of p1

h2_int

heritability intercept for p1

h2_int_se

SE of intercept

gcov_int

intercept of genetic covariance

gcov_int_se

SE of gcov

RELIABLE

A flag where the LDSC logs have or have not raised a potential issue

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