Omics data
As part of FinnGen 2 Expansion Area 5 (EA5), we piloted the functional characterization of approximately 100 Finnish-enriched coding variants that were associated with diseases of interest by adding proteomic, metabolomic, single-cell transcriptomic, and high-content cell imaging data.
The EA5 pilot was done in collaboration with the Blood Service Biobank, and the samples were collected from blood donors who were heterozyous or homozygous carriers of specific genetic variants of interest. The list of those variants of interest was suggested and approved by the Steering Committee at the beginning of the study and can be found here.
All data generated was from high-quality EDTA plasma that was processed and frozen within 4 hours (proteomics and metabolomics) and peripheral blood mononuclear cells (single-cell transcriptomics, immune profiling, and high-content cell imaging). In addition to the above-mentioned data, we have obtained full blood counts and standard clinical chemistry data from the same individuals.
During FinnGen 3, we aim to generate proteomic and single-cell transcriptomic data from approximately 10,000 FinnGen study subjects. The plan includes profiling samples based on the interests of the FinnGen 3 Task Forces and expanding the number of Finnish-enriched coding variant carriers.
Please check out the data-specific pages for additional information:
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